Toshimichi FUJIWARA | Nuclear Magnetic Resonance (NMR) for biology

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About this person

About this interview

We are interested in function and structure of biomolecular complexes such as proteins in membranes and fibrous proteins. The functions of biomolecules are based on molecular structures. The structures allow not only understanding the biological functions but also designing molecules useful for medicine and industry, such as drug and enzyme. However, it is generally difficult determine those structures defined by atomic coordinates. Thus we are developing new experimental technology for studying structure: nuclear magnetic resonance (NMR). This technology enables us to determine the structures of biomolecules not amenable to the other methods such as X-ray crystallography. The development of this method NMR requires expertise of various scientific fields, molecular biology, applied physics, physical chemistry and information technology. Therefore, we are conducting several research projects including the deveropment of high power terahertz light source and radio-frequency multiple pulses, application of molecular dynamics calculation, and reconstitution of biological molecular complexes.

Interview topics

  • Nuclear Magnetic Resonance for structure analysis of protein complexes [0:16]
  • NMR spectrometers
  • Expertise on biomolecular structures

Figures

Fig.1. Experimental apparatus.
Fig.2. Molecular model of cytoplasm/periplasm and the result of NMR.
Fig.3. Magnification of cytoplasm/periplasm.

Specialty

  • Application of high-sensitivity NMR to biological systems
  • Expertise on biomolecular structures

Keywords

  • Structural Biology
  • Nuclear Magnetic Resonance (NMR)
  • Biomacromolecule

Related website

 
0341_toshimichi_fujiwara.txt · Last modified: 2010/10/23 14:51 by zukan
 
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